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KMID : 0376319910030010267
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Dental Journal of CNU
1991 Volume.3 No. 1 p.267 ~ p.273
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The effect of fluoroaluminate on the proliferation of human gingival fibroblast
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Abstract
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Fluoride is widely used as a component of toothpaste for the prevention of dental caries. In this study, the fluoride >k effect on the proliferation of human gingival fibroblast in culture system was investigated. NaF at low concentrations (50 M-500 pM) stimulated cell proliferation. But, at higher concentrations(over 500 pM) gradually reduced the cell growths AJ.CL at low concentrations(5-20 pM) potentiated the cell growth stimulated by NaF. NaF induced the formation of inositol 1, 4, 5 trisphosphate in concentration-dependent manner. A1CL potentiated the IP3 formation induced t by NO.
These data suggested that the human gingival cell proliferation stimulated by fluoroaluminate, the combined from of Al-"- and F-, may be due to the activation of phosphoinositide-specific phospholipase C through guanine nucleotide-binding protein.
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